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After arginine is consumed in foods and in supplements, it makes its way into the bloodstream and circulates throughout the body. As it enters the endothelial cells that line the smooth muscle walls of blood vessels, an enzymatic reaction occurs that converts arginine to nitric oxide. As the levels of arginine rise in the body, so does your production of nitric oxide, which in turn can have a dramatic and positive effect on your cardiovascular health.

Nitric Oxide is produced in the endothelium of your 100,000 miles of arteries, capillaries, and veins!  Its production by vascular endothelium is particularly important in the regulation of  blood flow. Because of its importance in vascular function, abnormal production of NO, as occurs in different disease states, can adversely affect blood flow and other vascular functions.

The human body is wonderfully and fearfully made with the ability to heal itself.  What you do with this information is up to you. 

The next obvious questions would be:  "Why do we stop producing Nitric Oxide", and "How can we begin re-producing "NO"?

Age
Heart disease, diabetes, high blood pressure, cholesterol
Neurological damage
Arthritis, Allergies, Peptic ulcers
Prescription drugs (catch 22)
Alcohol, tobacco
Trans Fatty Acids (Fried foods, junk food)
Hypertension
Obesity

Diet and exercise help but it is not enough. It would take 24/7 to get enough exercise, and you could be eating nonstop.  Dr. Salvador Moncada from England discovered that the endothelium uses a naturally occurring amino acid to make nitric oxide called L-Arginine.

The Solution!  L-Arginine

L-Arginine produces Nitric Oxide in the endothelium of our vessels and keeps our cardiovascular system working optimally!

Direct vasodilation - (opens up vessels)
Indirect vasodilation by inhibiting vasoconstrictor influences
Anti-thrombotic effect - (prevention of blood clots)
Anti-inflammatory effect 
Anti-proliferative effect - (inhibits smooth muscle hyperplasia)

Vascular actions of Nitric Oxide include the following:
Dr. Ferid Murad
Dr. Louise J. Ignarro
1.  Nitric Oxide is produced in healthy arteries
2.  Nitric Oxide is diminished in our arteries as we introduce unhealthy lifestyles
     and as we age
          a.  arteries begin to stiffen
          b.  artery lining (endothelium) begins to crack
3.  The debris such as cholesterol begins to accumulate under the lining as it
      seeps into the little cracks that begin.  In addition the debris sticks to the
      outside of the lining
4.  The lumen (opening) begins to narrow as this plaque build up thickens
      leaving us susceptible to disease processes
5.   Left unchecked, the oxygen and nutrient rich blood supply is cut off which
      leads to heart attacks and strokes
is Loaded with L-Arginine!

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Dr. Robert Furchgott
Nitric oxide (also known as "NO") is a gas that functions as a signaling molecule (neurotransmitter) telling your body to make blood vessels relax and widen.  As a gas, you are unable to supplement with it but we CAN take l-arginine which converts to nitric oxide.

Nitric Oxide
The Discovery!

Stockholm, Sweeden, Oct. 12, 1998



Three Americans won the Nobel Prize in Medicine for discovering that the body uses nitric oxide gas to make blood vessels relax and widen.  A finding that could pay off in treatments for heart disease.  - Associated Press

     Nitric oxide is required by the human body. Deficiency can cause muscle weakness, physical weakness and fatigued feeling. Nitric oxide is used in many basic functions including blood vessel dilatation, penile erections, reducing blood pressure and neurotransmission or communication between cells. Nitric oxide increases stamina. Nitric oxide fights pathogens and helps the endocrine system. Increased libido is another common effect of nitric oxide.

     Nitric Oxide dilates the vessels and increases blood flow.  It Increases oxygen supply & protects the heart and other organs from damage and cell death.  (NO) will keep vessels pliable and elastic, keeping blood flowing smoothly, relax blood vessels, keep platelets and white blood cells calm and prevent them from sticking to the vessel wall, prevent oxidation, slow plaque growth, suppress arteriosclerosis and melt away plaque that already exists.

     Dr. Jonathan S. Stamler, Professor of Medicine Duke University Medical Center states: "It does everything, everywhere. You cannot name a major cellular response or physical effect in which NO is not implicated today. Its involved in complex behavioral changes in the brain, airway relaxation, beating of the heart, dilation of blood vessels, regulation of intestinal movement, function of blood cells, the immune system, even the way fingers and arms move."

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